In order to identify potential diagnostic and prognostic biomarkers, and treatment targets for head and neck squamous cell carcinoma (HNSCC), the present study obtained the gene expression profiles in HNSCC through public data mining, and core genes were identified using a series of bioinformatics analysis methods and databases. A total of nine hub genes (SPP1, ITGA6, TMPRSS11D, MMP1, LAMC2, FAT1, ACTA1, SERPINE1 and CEACAM1) were identified to be significantly correlated with HNSCC. Furthermore, overall survival analysis demonstrated that the expression values of hub genes were associated with overall survival in HNSCC. Furthermore, certain of the identified genes, including, TMPRSS11D, ACTA1 and CEACAM1, have not been thoroughly investigated in HNSCC previously. Taken together, the nine hub genes obtained by screening in the present study may serve as potential tumor markers and important prognostic indicators for HNSCC.
基金：
Key Program of Hebei Natural Science Foundation [H2017206391]; Project of Clinical Medical Talent Training and Basic Project Research Funded by Government [grant Hebei finance society] [46]
第一作者机构：[1]Hebei Med Univ, Hosp 2, Dept Otorhinolaryngol, 215 Heping West Rd, Shijiazhuang 050000, Hebei, Peoples R China[2]Hebei Univ, Affiliated Hosp, Dept Otorhinolaryngol, Baoding 071000, Hebei, Peoples R China
通讯作者：
通讯机构：[1]Hebei Med Univ, Hosp 2, Dept Otorhinolaryngol, 215 Heping West Rd, Shijiazhuang 050000, Hebei, Peoples R China[*1]Department of Otorhinolaryngology, The Second Hospital of Hebei Medical University, 215 Heping West Road, Shijiazhuang, Hebei 050000, P.R. China
推荐引用方式(GB/T 7714)：
Zhao Lei,Chi Weiwei,Cao Huan,et al.Screening and clinical significance of tumor markers in head and neck squamous cell carcinoma through bioinformatics analysis[J].MOLECULAR MEDICINE REPORTS.2019,19(1):143-154.doi:10.3892/mmr.2018.9639.
APA：
Zhao, Lei,Chi, Weiwei,Cao, Huan,Cui, Weina,Meng, Wenxia...&Wang, Baoshan.(2019).Screening and clinical significance of tumor markers in head and neck squamous cell carcinoma through bioinformatics analysis.MOLECULAR MEDICINE REPORTS,19,(1)
MLA：
Zhao, Lei,et al."Screening and clinical significance of tumor markers in head and neck squamous cell carcinoma through bioinformatics analysis".MOLECULAR MEDICINE REPORTS 19..1(2019):143-154
