In the contemporary medical landscape, the burgeoning interest in natural therapies, particularly for managing gastrointestinal disorders, has brought traditional Chinese medicine (TCM) to the forefront. This article explains the core principles and clinical applications of TCM in treating these conditions, furthering the discourse through an examination of integrated TCM strategies, as demonstrated in the study by Zhou et al. While TCM has shown promising clinical outcomes, it encounters significant hurdles in standardization, mechanistic research, and clinical validation. Future investigations should aim to solidify the scientific underpinnings of TCM and expand its use in gastrointestinal disease management, striving for a seamless fusion of traditional and contemporary medical practices.©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.