To investigate the variations and clinical implications of serum Gal-3 and IL-6 values in individuals with heart failure (HF) complicated with renal impairment.Analytical study. Place and Duration of the Study: Department of Nephrology, The Affiliated Hospital of Hebei University, Baoding, Hebei, China, from May 2022 to 2023.A total of 80 HF individuals who were treated in the Department of Nephrology, The Affiliated Hospital of Hebei University, Baoding, Hebei, China, from May 2022 to 2023, were classified into the normal renal function band (n = 40) and the renal impairment band (n = 40) according to glomerular filtration rate (eGFR). The serum galactose-3 (Gal-3) and interleukin-6 (IL-6) values and their correlation with renal impairment were compared between the two bands, along with an analysis of the sensitivity and specificity of Gal-3 and IL-6 using receiver operating characteristic (ROC) curves.There were higher Gal-3 and IL-6 values in the renal impairment band, in contrast to the normal renal function band (p <0.05). Spearman's correlation analysis indicated a significant association between Gal-3 and IL-6 values in HF individuals and renal impairment (p <0.05). The AUC values of Gal-3 and IL-6 in predicting renal impairment in HF individuals were <0.914 and <0.717, respectively; the specificity of Gal-3 and IL-6 in predicting renal impairment was 70.00% and 62.50%, respectively, the sensitivity was 97.50% and 80.00%, respectively.HF individuals complicated with renal impairment have increased serum Gal-3 and IL-6 values, both of which are significantly associated with renal impairment.Heart failure, Renal impairment, Galactose lectin-3, Interleukin-6 protein.