Introduction: Cognitive impairment, especially memory dysfunction, is the hallmark symptom of Alzheimers Disease (AD) and other forms of dementia1. Donepezil hydrochloride is a commonly used acetylcholinesterase inhibitor, mainly used to delay cognitive decline2 in these patients. Although pharmacological treatments such as donepezil are able to relieve symptoms, non-pharmacological interventions such as mental movie animation have received increasing attention in recent years, which stimulate cognitive function through visual and emotional stimuli. The aim of this study was to investigate the effect of mental movie animation combined with donepezil hydrochloride on the recovery of memory function in patients with cognitive impairment.