Hepatocellular carcinoma (HCC) is one of the leading causes of cancer-related mortality worldwide. This study investigates the role and mechanisms of ADAM9 as a biomarker and potential therapeutic target in HCC. Utilizing RNA-sequencing data and clinicopathological characteristics from The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) databases, we conducted survival and meta-analyses, functional enrichment, and immune infiltration studies. Additionally, we evaluated the effects of ADAM9 silencing on HCC cell proliferation, migration, and invasion through in vitro experiments. Our results demonstrate that high ADAM9 expression is associated with poor prognosis and increased immune infiltration in HCC patients. Furthermore, ADAM9 knockdown significantly inhibited tumor cell proliferation and migration. These findings indicate that ADAM9 is a promising prognostic biomarker and potential therapeutic target in HCC. In conclusion, ADAM9 could offer avenues for developing strategies to inhibit tumor progression and improve patient outcomes.
基金：
Chongqing technology innovation and application development key project (cstc2021jscx-gksbX0060), Chongqing science and health joint project (2024GGXM005) and Chongqing Research Performance Incentive and Guidance Project (cstc2022jxjl120032).
第一作者机构：[1]Chongqing Med Univ, Affiliated Hosp 1, Dept Hepatobiliary Surg, 1 Youyi Rd, Chongqing 400016, Peoples R China
共同第一作者：
通讯作者：
通讯机构：[1]Chongqing Med Univ, Affiliated Hosp 1, Dept Hepatobiliary Surg, 1 Youyi Rd, Chongqing 400016, Peoples R China[7]Chongqing Univ, Canc Hosp, Dept Hepatobiliary Pancreat Tumor Ctr, Chongqing, Peoples R China
推荐引用方式(GB/T 7714)：
Jiang Liqing,Huang Weifeng,Cao Mulan,et al.Deciphering the oncogenic potential of ADAM9 in hepatocellular carcinoma through bioinformatics and experimental approaches[J].SCIENTIFIC REPORTS.2024,14(1):doi:10.1038/s41598-024-74650-8.
APA：
Jiang, Liqing,Huang, Weifeng,Cao, Mulan,Jiang, Yingsong,Li, Simin...&Huang, Zuotian.(2024).Deciphering the oncogenic potential of ADAM9 in hepatocellular carcinoma through bioinformatics and experimental approaches.SCIENTIFIC REPORTS,14,(1)
MLA：
Jiang, Liqing,et al."Deciphering the oncogenic potential of ADAM9 in hepatocellular carcinoma through bioinformatics and experimental approaches".SCIENTIFIC REPORTS 14..1(2024)
