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CuO nanoparticles for glioma treatment in vitro and in vivo

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机构: [1]School of Clinical Medicine, Hebei University, Baoding 071000, China. [2]Key Laboratory of Precise Diagnosis and Treatment of Glioma in Hebei Province, Baoding 071000, China. [3]Department of Neurosurgery, Zhejiang Provincial People’s Hospital, Affiliated to Hangzhou Medical College, Hangzhou 310000, Zhejiang, China. [4]Department of Neurosurgery, Affiliated Hospital of Hebei University, Baoding 071000, China.
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关键词: CuO nanoparticles Cerebral glioma Tumor therapy Nano-medicine Security application

摘要:
Glioma is the most prevalent malignant brain tumor in adults. The development of engineered nanomaterials (ENMs) has led to the emergence of innovative therapeutic strategies for gliomas. Therefore, our aim is to investigate the therapeutic effect of CuO nanoparticles (NPs) on glioma and provide data support for future research. The therapeutic effect of CuO NPs on glioma rats was explored through the detection of inflammatory factors, oxidase, pathological sections, immunofluorescence, neurotransmitter, glioma biomarker proteins and genes, and rat behavioral tests. Additionally, the application prospect of CuO NPs was evaluated by treating U87MG human glioma cell line. In this study, it was found that CuO NPs can alleviate the inflammatory reaction in the hippocampus tissue of glioma rats, promote the production of ·OH and lead to the up-regulation of catalase (CAT) and superoxide dismutase (SOD) enzyme activities. Treatment with CuO NPs also inhibited the expression of matrix metalloproteinase-9 (MMP-9) biomarkers in model rats and glioma cells. Moreover, it enhanced the release of neurotransmitters, which subsequently improved spatial recognition and memory ability of glioma rats. In conclusion, CuO NPs is a potential glioma treatment for ENMs, but still needs modification and modification strategies to improve its biocompatibility and targeted delivery.© 2024. The Author(s).

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大类 | 3 区 综合性期刊
小类 | 3 区 综合性期刊
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Q1 MULTIDISCIPLINARY SCIENCES

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第一作者机构: [1]School of Clinical Medicine, Hebei University, Baoding 071000, China. [2]Key Laboratory of Precise Diagnosis and Treatment of Glioma in Hebei Province, Baoding 071000, China. [4]Department of Neurosurgery, Affiliated Hospital of Hebei University, Baoding 071000, China.
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通讯机构: [1]School of Clinical Medicine, Hebei University, Baoding 071000, China. [2]Key Laboratory of Precise Diagnosis and Treatment of Glioma in Hebei Province, Baoding 071000, China.
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