Rosa laevigata Michx. Polysaccharide Ameliorates Diabetic Nephropathy in Mice through Inhibiting Ferroptosis and PI3K/AKT Pathway-Mediated Apoptosis and Modulating Tryptophan Metabolism
机构：[1]Hebei Univ Chinese Med, Cangzhou Hosp Integrated Tradit Chinese Med & West, Cangzhou, Peoples R China[2]Grad Sch Chengde Med Univ, Grad Sch, Chengde, Peoples R China[3]Hebei Univ Chinese Med, Grad Sch, Shijiazhuang, Peoples R China[4]Yunnan Univ Tradit Chinese Med, Kunming, Peoples R China
Diabetic nephropathy (DN) is a metabolic disease wherein chronic hyperglycemia triggers various renal cell dysfunctions, eventually leading to progressive kidney failure. Rosa laevigata Michx. is a traditional Chinese herbal medicine. Many studies have confirmed its antioxidative, anti-inflammatory, and renoprotective effects. However, the effects and mechanisms of Rosa laevigata Michx. polysaccharide (RLP) in DN remain unclear. In this study, a DN mouse model was established to investigate the therapeutic effect of RLP on DN mice. Then, nontargeted metabolomics was used to analyze the potential mechanism of RLP in the treatment of DN. Finally, the effects of RLP on ferroptosis and the PI3K/AKT pathway were investigated. The results demonstrated that RLP effectively alleviated renal injury and reduced inflammation and oxidative stress in the kidney. In addition, nontargeted metabolomic analysis indicated that RLP could modulate riboflavin metabolism and tryptophan metabolism in DN mice. Notably, ferroptosis and PI3K/AKT pathway-mediated apoptosis in the kidney were also ameliorated following RLP treatment. In conclusion, this study confirmed that RLP had a significant therapeutic effect on DN mice. Furthermore, RLP treatment modulated tryptophan metabolism and inhibited ferroptosis and PI3K/AKT pathway-mediated apoptosis in the kidney.
基金：
This study was supported by the Construction Project of Workshop of Prestigious Chinese Physician (2022-75) and Hebei Province Administration of Traditional Chinese Medicine scientific research project (2024488). [2022-75]; Hebei Province Administration of Traditional Chinese Medicine scientific research project [2024488]
语种：
外文
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PubmedID：
中科院(CAS)分区：
出版当年[2025]版：
大类|3 区医学
小类|3 区内分泌学与代谢3 区医学：研究与实验
最新[2025]版：
大类|3 区医学
小类|3 区内分泌学与代谢3 区医学：研究与实验
JCR分区：
出版当年[2023]版：
Q2ENDOCRINOLOGY & METABOLISMQ2MEDICINE, RESEARCH & EXPERIMENTAL
最新[2023]版：
Q2ENDOCRINOLOGY & METABOLISMQ2MEDICINE, RESEARCH & EXPERIMENTAL
第一作者机构：[1]Hebei Univ Chinese Med, Cangzhou Hosp Integrated Tradit Chinese Med & West, Cangzhou, Peoples R China
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推荐引用方式(GB/T 7714)：
Zhang Tianyu,Sun Wenjuan,Wang Lixin,et al.Rosa laevigata Michx. Polysaccharide Ameliorates Diabetic Nephropathy in Mice through Inhibiting Ferroptosis and PI3K/AKT Pathway-Mediated Apoptosis and Modulating Tryptophan Metabolism[J].JOURNAL OF DIABETES RESEARCH.2023,2023:doi:10.1155/2023/9164883.
APA：
Zhang, Tianyu,Sun, Wenjuan,Wang, Lixin,Zhang, Hui,Wang, Yuansong...&Lv, Shuquan.(2023).Rosa laevigata Michx. Polysaccharide Ameliorates Diabetic Nephropathy in Mice through Inhibiting Ferroptosis and PI3K/AKT Pathway-Mediated Apoptosis and Modulating Tryptophan Metabolism.JOURNAL OF DIABETES RESEARCH,2023,
MLA：
Zhang, Tianyu,et al."Rosa laevigata Michx. Polysaccharide Ameliorates Diabetic Nephropathy in Mice through Inhibiting Ferroptosis and PI3K/AKT Pathway-Mediated Apoptosis and Modulating Tryptophan Metabolism".JOURNAL OF DIABETES RESEARCH 2023.(2023)
