Objective center dot To investigate the value of comprehensive rehabilitation therapy in chronic obstructive pulmonary disease (COPD) and its effect on improvement in patients' inflammation. Methods center dot A total of 174 patients with acute COPD exacerbation in the Affiliated Hospital of Hebei University in China from March 2020 to January 2022 were selected as research subjects. They were divided into control, acute and stable groups according to the random number table method (n=58 in each group). The control group was given conventional treatment; the acute group started comprehensive rehabilitation treatment in the acute phase; in the stable group, comprehensive rehabilitation treatment was initiated in the stable period after the condition was stabilized with conventional treatment. Tumor necrosis factor-a (TNF-alpha), high-sensitivity C-reactive protein (hs-CRP), interleukin-6 (IL-6) and pulmonary function were measured before and after treatment, with the forced expiratory volume in 1 second (FEV1), forced expiratory volume in 1 second/forced vital capacity (FEV1/FVC) ratio, and peak expiratory flow rate (PEF). A 6-min walk test (6MWD) was performed on the patient, and the ability to perform activities of daily living (ADL), selfrating anxiety scale (SAS) and self-rating depression scale (SDS) were used to assess patients' ability to perform ADL and psychology. Finally, the incidence of adverse events (AEs) in patients was recorded and a quality of life (QoL) survey was completed. Results center dot The 6MWD test, ADL, FEV1, FEV1/FVC and PEF were elevated in the acute and stable groups compared with the control group, whereas shortness of breath, TNF-alpha, hs-CRP and IL-6 were decreased (P <.05). SAS and SDS scores were reduced in the acute and stable groups after treatment (P <.05), while there was no change in the control group (P >.05). In addition, QoL was higher in the acute and stable groups (P <.05). The improvement of all indicators in the acute group was better than in the stable group (P <.05). Conclusion center dot Comprehensive rehabilitation therapy can improve the exercise capacity and lung function of patients with COPD, reduce inflammation, and improve patients' negative psychology.