机构：[1]Department of Gastroenterology, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy ofMedical Sciences, Beijing, China,[2]Department of Gastroenterology, The Sixth Hospital of Beijing, Beijing, China,[3]Department ofGastroenterology, Affiliated Hospital of Hebei University, Baoding, China,河北大学附属医院[4]Department of Gastroenterology, Beijing Fangshan DistrictLiangxiang Hospital, Beijing, China,[5]Department of Gastroenterology, The First People’s Hospital of Longquanyi District, Chengdu,China,[6]Department of Gastroenterology, People’s Liberation Army the General Hospital of Western Theater Command, Chengdu,China,[7]Department of Gastroenterology, The Fourth Affiliated Hospital of Harbin Medical University, Harbin, China,[8]Medical ResearchCenter, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing,China,[9]State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Peking Union MedicalCollege and Chinese Academy of Medical Sciences, Beijing, China,[10]Clinical Epidemiology Unit, International Clinical Epidemiology Network, Beijing, China
Background: Hypertriglyceridemia (HTG) is a major cause of acute pancreatitis (AP). We aimed to determine whether HTG is an independent risk factor for AP complications and construct a prediction model for non-mild AP.Methods: We conducted a multi-center cohort study including 872 patients with AP and divided them into HTG-AP and non-HTG-AP groups. Multivariate logistic regression was performed, and a prediction model for non-mild HTG-AP was developed.Results: HTG-AP patients had a higher risk of systemic complications, including systemic inflammatory response syndrome [odds ratio (OR): 1.718; 95% confidence interval (CI): 1.286-2.295], shock (OR: 2.103; 95%CI: 1.236-3.578), acute respiratory distress syndrome (OR: 2.231; 95%CI: 1.555-3.200), acute renal failure (OR: 1.593; 95%CI: 1.036-2.450), and local complications such as acute peri-pancreatic fluid collection (OR: 2.072; 95%CI: 1.550-2.771), acute necrotic collection (OR: 1.996; 95% CI: 1.394-2.856), and walled-off necrosis (OR: 2.157; 95%CI: 1.202-3.870). The area under curve of our prediction model was 0.898 (95%CI: 0.857-0.940) and 0.875 (95%CI: 0.804-0.946) in the derivation and validation datasets respectively.Conclusion: HTG is an independent risk factor for AP complications. We constructed a simple and accurate prediction model for progression of non-mild AP.
基金：
National Natural Science Founda-tion of China [32170788]
第一作者机构：[1]Department of Gastroenterology, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy ofMedical Sciences, Beijing, China,[9]State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Peking Union MedicalCollege and Chinese Academy of Medical Sciences, Beijing, China,
共同第一作者：
通讯作者：
通讯机构：[9]State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Peking Union MedicalCollege and Chinese Academy of Medical Sciences, Beijing, China,[10]Clinical Epidemiology Unit, International Clinical Epidemiology Network, Beijing, China[*1]Department of Gastroenterology, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Dongcheng District, 100730, Beijing, China.
推荐引用方式(GB/T 7714)：
Song Kai,Wu Zuoyan,Meng Jie,et al.Hypertriglyceridemia as a risk factor for complications of acute pancreatitis and the development of a severity prediction model[J].HPB.2023,25(9):1065-1073.doi:10.1016/j.hpb.2023.05.006.
APA：
Song, Kai,Wu, Zuoyan,Meng, Jie,Tian, Wei,Zheng, Shicheng...&Wu, Dong.(2023).Hypertriglyceridemia as a risk factor for complications of acute pancreatitis and the development of a severity prediction model.HPB,25,(9)
MLA：
Song, Kai,et al."Hypertriglyceridemia as a risk factor for complications of acute pancreatitis and the development of a severity prediction model".HPB 25..9(2023):1065-1073
