机构：[1]School of Basic Medical Science, Hebei University, Baoding, Hebei, P. R. China[2]College of Traditional Chinese Medicine, Hebei University, Baoding, Hebei, P. R. China[3]Affiliated Hospital of Hebei University, Baoding, Hebei, P. R. China河北大学附属医院[4]Clinical Medical College, Hebei University, Baoding, Hebei, P. R. China[5]Hebei Collaborative Innovation Center of Tumor Microecological Metabolism Regulation, Baoding, Hebei, P. R. China
Objectives To review the pharmacokinetics, pharmacological action and mechanism of isoalantolactone (IAL). Explore the therapeutic potential of isoalantolactone. Keywords including isoalantolactone, pharmacological effects, pharmacokinetic and toxicity were used for literature search in PubMed, Excerpta Medica Database (EMBASE) and Web of Science, to identify articles published from 1992 to 2022. Key findings IAL has a great many obiological activities such as anti-inflammatory, antioxidant, antitumour, neuroprotection, with no obvious toxicity. This review suggests that IAL exerts different pharmacological effects with different mechanisms of action at different doses, and may be a potential drug candidate to treat inflammatory diseases, neurodegenerative diseases and cancer, with medicinal value. IAL has various pharmacological activities and medicinal values. However, further research is needed to determine its specific intracellular action sites and targets, so as to fully understand its therapeutic mechanism and provide a reference for the treatment of related diseases.
基金：
Natural Science Foundation of Hebei Province, Hebei Province, China [H2021201043]; Training Program for Outstanding Clinical Medical Talents, Hebei Province, China; Outstanding Youth Scientific Research and Innovation Team (Science and Technology) Project of Hebei University, Hebei Province, China [2020-8]
第一作者机构：[1]School of Basic Medical Science, Hebei University, Baoding, Hebei, P. R. China
通讯作者：
通讯机构：[1]School of Basic Medical Science, Hebei University, Baoding, Hebei, P. R. China[3]Affiliated Hospital of Hebei University, Baoding, Hebei, P. R. China[4]Clinical Medical College, Hebei University, Baoding, Hebei, P. R. China[5]Hebei Collaborative Innovation Center of Tumor Microecological Metabolism Regulation, Baoding, Hebei, P. R. China[*1]School of Basic Medical Science, Hebei University, Baoding 071000, Hebei Province, P. R. China[*2]Affiliated Hospital of Hebei University, Baoding 071000, Hebei Province, P. R. China
推荐引用方式(GB/T 7714)：
Xu Lu,Sun Yanan,Cai Qihan,et al.Research progress on pharmacological effects of isoalantolactone[J].JOURNAL OF PHARMACY AND PHARMACOLOGY.2023,75(5):585-592.doi:10.1093/jpp/rgac103.
APA：
Xu, Lu,Sun, Yanan,Cai, Qihan,Wang, Mengmeng,Wang, Xinliang...&Ni, Zhiyu.(2023).Research progress on pharmacological effects of isoalantolactone.JOURNAL OF PHARMACY AND PHARMACOLOGY,75,(5)
MLA：
Xu, Lu,et al."Research progress on pharmacological effects of isoalantolactone".JOURNAL OF PHARMACY AND PHARMACOLOGY 75..5(2023):585-592
