Oral cancer is one of the 10 most common cancers in the world, which brings heavy burden for public health. Although several drugs were recommended to treat oral cancer, while it is needed to investigate the pathogen-esis and develop novel treatment for this type of cancer. In the study, two oral cancer cell lines including HSC-6 and CAL-27 were used. It was found that rapamycin potently inhibited proliferation of HSC-6 and CAL-27 cells. Rapamycin significantly induced apoptosis and reduced cell viability of HSC-6 and CAL-27 cells. Rapamycin inhibited growth of oral cancer cells via mTOR. Moreover, it was found that mTOR was highly expresses in PBMC of oral cancer patients compared with PBMC of healthy controls. Rapamycin increased expression of miR-199a-3p and miR-199-3p was highly expression in oral cancer patients. Importantly, it was confirmed that rapamycin suppressed proliferation and promoted apoptosis of oral cancer cells via miR-199a-3p. The findings of the present study will provideIP: useful203.8.109.20insights forOn: Wd,developing 01 Feb novel2023 therapies16:21:08of oral cancer.
基金：
Med-ical Science Research Project of Hebei Provincial Health-care Commission [20221256]
第一作者机构：[1]Hebei Univ, Affiliated Hosp, Dept Stomatol, Baoding 071000, Hebei, Peoples R China
通讯作者：
推荐引用方式(GB/T 7714)：
Hou Yujiao,Lv Feifei,Zhai Wenjing,et al.Rapamycin Inhibits Human Oral Cancer Cell Growth via the Hsa-miR-199a-3p/mTOR Pathway[J].SCIENCE OF ADVANCED MATERIALS.2022,14(9):1466-1475.doi:10.1166/sam.2022.4369.
APA：
Hou, Yujiao,Lv, Feifei,Zhai, Wenjing,Wang, Weina,Duan, Yanhao...&Qiu, Yongle.(2022).Rapamycin Inhibits Human Oral Cancer Cell Growth via the Hsa-miR-199a-3p/mTOR Pathway.SCIENCE OF ADVANCED MATERIALS,14,(9)
MLA：
Hou, Yujiao,et al."Rapamycin Inhibits Human Oral Cancer Cell Growth via the Hsa-miR-199a-3p/mTOR Pathway".SCIENCE OF ADVANCED MATERIALS 14..9(2022):1466-1475
