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Brain tumors: Cancer stem-like cells interact with tumor microenvironment

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机构: [1]Department of Neurosurgery, Chinese PLA General Hospital,Beijing 100853, China [2]Department of Pathology, Affiliated Hospital of Hebei University, Baoding071000, Hebei Province, China
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关键词: Cancer stem-like cells Microenvironment Brain tumor Inflammation Clinical application Glioma

摘要:
Cancer stem-like cells (CSCs) with potential of self-renewal drive tumorigenesis. Brain tumor microenvironment (TME) has been identified as a critical regulator of malignancy progression. Many researchers are searching new ways to characterize tumors with the goal of predicting how they respond to treatment. Here, we describe the striking parallels between normal stem cells and CSCs. We review the microenvironmental aspects of brain tumors, in particular composition and vital roles of immune cells infiltrating glioma and medulloblastoma. By highlighting that CSCs cooperate with TME via various cellular communication approaches, we discuss the recent advances in therapeutic strategies targeting the components of TME. Identification of the complex and interconnected factors can facilitate the development of promising treatments for these deadly malignancies.

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出版当年[2021]版
大类 | 3 区 生物
小类 | 3 区 细胞与组织工程 4 区 细胞生物学
最新[2025]版
大类 | 3 区 医学
小类 | 3 区 细胞与组织工程 3 区 细胞生物学
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出版当年[2020]版:
Q2 CELL BIOLOGY Q2 CELL & TISSUE ENGINEERING
最新[2023]版:
Q3 CELL & TISSUE ENGINEERING Q3 CELL BIOLOGY

影响因子: 最新[2023版] 最新五年平均 出版当年[2020版] 出版当年五年平均 出版前一年[2019版] 出版后一年[2021版]

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第一作者机构: [1]Department of Neurosurgery, Chinese PLA General Hospital,Beijing 100853, China
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通讯机构: [1]Department of Neurosurgery, Chinese PLA General Hospital,Beijing 100853, China [*1]Department of Neurosurgery, ChinesePLA General Hospital, No. 28 Fuxing Road, Haidian District, Beijing 100853, China.
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