机构:[1]Department of Neurosurgery, Chinese PLA General Hospital,Beijing 100853, China[2]Department of Pathology, Affiliated Hospital of Hebei University, Baoding071000, Hebei Province, China河北大学附属医院
Cancer stem-like cells (CSCs) with potential of self-renewal drive tumorigenesis. Brain tumor microenvironment (TME) has been identified as a critical regulator of malignancy progression. Many researchers are searching new ways to characterize tumors with the goal of predicting how they respond to treatment. Here, we describe the striking parallels between normal stem cells and CSCs. We review the microenvironmental aspects of brain tumors, in particular composition and vital roles of immune cells infiltrating glioma and medulloblastoma. By highlighting that CSCs cooperate with TME via various cellular communication approaches, we discuss the recent advances in therapeutic strategies targeting the components of TME. Identification of the complex and interconnected factors can facilitate the development of promising treatments for these deadly malignancies.
基金:
Medical Big Data Research Program of Chinese PLA General Hospital [2018MBD-20]; National Natural Science Foundation of China [81902975]; 65th China Postdoctoral Science Foundation [2019M653940]
第一作者机构:[1]Department of Neurosurgery, Chinese PLA General Hospital,Beijing 100853, China
共同第一作者:
通讯作者:
通讯机构:[1]Department of Neurosurgery, Chinese PLA General Hospital,Beijing 100853, China[*1]Department of Neurosurgery, ChinesePLA General Hospital, No. 28 Fuxing Road, Haidian District, Beijing 100853, China.
推荐引用方式(GB/T 7714):
Liu Hai-Long,Wang Ya-Nan,Feng Shi-Yu.Brain tumors: Cancer stem-like cells interact with tumor microenvironment[J].WORLD JOURNAL OF STEM CELLS.2020,12(12):1439-1454.doi:10.4252/wjsc.v12.i12.1439.
APA:
Liu, Hai-Long,Wang, Ya-Nan&Feng, Shi-Yu.(2020).Brain tumors: Cancer stem-like cells interact with tumor microenvironment.WORLD JOURNAL OF STEM CELLS,12,(12)
MLA:
Liu, Hai-Long,et al."Brain tumors: Cancer stem-like cells interact with tumor microenvironment".WORLD JOURNAL OF STEM CELLS 12..12(2020):1439-1454