机构：[1]Hebei Univ Chinese Med, Fac Integrated Tradit Chinese & Western Med, Shijiazhuang 050091, Hebei, Peoples R China[2]Hebei Univ,Affiliated Hosp,Hebei Key Lab Canc Radiotherapy & Chemotherapy,Dept Med Oncol,Baoding 071000,Peoples R China医疗肿瘤内科重点实验室河北省肿瘤放化疗机制与规程研究重点实验室河北大学附属医院重点学科肿瘤内科[3]Hebei Univ,Affiliated Hosp,Dept Neurosurg,Baoding 071000,Peoples R China医疗神经外科河北大学附属医院重点学科神经外科[4]Cangzhou Cent Hosp, Dept Gen Surg, Endoscopy Div, Cangzhou 061000, Peoples R China[5]Hebei Univ Chinese Med, Fac Acupuncture Moxibust & Tuina, Shijiazhuang 050091, Hebei, Peoples R China
Aim: This review aims to systematically describe the biogenesis and degradation of circular RNAs (circR-NAs), discusses the major functions of circRNAs, introduces the mechanisms by which circRNAs play a role in cancer, comprehensively summarize the relationship between circRNAs and anticarcinogen resistance as well as underlying specific mechanisms in multiple cancers. Materials & methods: We screened and analyzed large quantity of scientific papers which associated with circRNAs, noncoding RNAs, function, cancer, drug resistance and chemoresistance, and then summarized in Figures 1 & 2 & Table 1. Results & conclusion: The biogenesis, degradation and function of circRNAs are specially compared with other noncoding RNAs, it can affect cancer pathogenesis and progression and are implicated in mediating resistance to various anticarcinogens in various types of cancer.
基金：
Science and Technology Capacity Improvement Projects of Hebei University of Chinese Medicine in 2019 [KTZ2019019]; Outstanding Student Scientific Research Ability Improvement Projects of Hebei University of Chinese Medicine in 2019 [YXZ2019002]; Graduate Innovative Ability Training Projects of Hebei Province in 2020
