Ce6-Conjugated and polydopamine-coated gold nanostars with enhanced photoacoustic imaging and photothermal/photodynamic therapy to inhibit lung metastasis of breast cancer
机构：[1]Key Laboratory of Medicinal Chemistry and Molecular Diagnosis of the Ministry of Education, Chemical Biology Key Laboratory of Hebei Province, College of Chemistry& Environmental Science, Institute of Life Science and Green Development, HebeiUniversity, Baoding 071002, P.R. China[2]Medical Department & Affiliated Hospital of Hebei University, Baoding 071002, P.R.China[3]Cixi Institute of Biomedical Engineering, CAS Key Laboratory of Magnetic Materialsand Devices, Ningbo Institute of Materials Technology and Engineering, ChineseAcademy of Sciences, Ningbo, 315201, P.R. China
Metastasis is the main cause of treatment failure in breast cancer, and integrated phototheranostics is a promising strategy to achieve both precision theranostics and metastasis inhibition. In this work, a multifunctional phototheranostic nanoprobe composed of chlorin e6 (Ce6)-conjugated and polydopamine (PDA)-coated gold nanostars (AuNSs) was synthesized for simultaneous photoacoustic (PA) imaging, photothermal therapy (PTT) and photodynamic therapy (PDT). Under the irradiation of near infrared laser, AuNSs@PDA showed enhanced photothermal conversion and amplified PA imaging performance, compared with single AuNSs. By the covalent conjugation of Ce6, the AuNSs@PDA-Ce6 nanoprobe showed robust stability and excellent singlet oxygen (O-1(2)) generation ability. Under the combination of PTT/PDT, the AuNSs@PDA-Ce6 nanoprobes significantly reduced the growth of 4T1 tumors and suppressed their lung metastasis. All the results demonstrated the considerable potential of AuNSs@PDA-Ce6 phototheranostic nanoprobes for precision theranostics and metastasis inhibition of breast cancer.
基金：
National Natural Science Foundation of China [51772074, U1732127, U1332117]; Youth Top-notch Talents of Education Department of Hebei Province [BJ2017002]; Natural Science Foundation of Hebei Province [C2020201025]; Advanced Talents Incubation Program of Hebei University [521000981076]; Undergraduate Innovation and Entrepreneurship Training Program of Hebei University [2020051]
第一作者机构：[1]Key Laboratory of Medicinal Chemistry and Molecular Diagnosis of the Ministry of Education, Chemical Biology Key Laboratory of Hebei Province, College of Chemistry& Environmental Science, Institute of Life Science and Green Development, HebeiUniversity, Baoding 071002, P.R. China
通讯作者：
推荐引用方式(GB/T 7714)：
Li Ziwei,Yang Fan,Wu Di,et al.Ce6-Conjugated and polydopamine-coated gold nanostars with enhanced photoacoustic imaging and photothermal/photodynamic therapy to inhibit lung metastasis of breast cancer[J].NANOSCALE.2020,12(43):22173-22184.doi:10.1039/d0nr05386d.
APA：
Li, Ziwei,Yang, Fan,Wu, Di,Liu, Yanhong,Gao, Yang...&Zeng, Leyong.(2020).Ce6-Conjugated and polydopamine-coated gold nanostars with enhanced photoacoustic imaging and photothermal/photodynamic therapy to inhibit lung metastasis of breast cancer.NANOSCALE,12,(43)
MLA：
Li, Ziwei,et al."Ce6-Conjugated and polydopamine-coated gold nanostars with enhanced photoacoustic imaging and photothermal/photodynamic therapy to inhibit lung metastasis of breast cancer".NANOSCALE 12..43(2020):22173-22184
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