The direct coupling of 2-carbonyl-anilines and diazo-cyclopentanones, promoted by a rhodium catalyst and diphenyl phosphate, is reported for the divergent generation of both carbazolones and indolones. The strategy allows for the successful transfer of the substituents/functionality and the chirality of the coupling partners into the functionalized heterocyclic products, thus serving as the strategic basis for natural product synthesis as demonstrated by the concise asymmetric total synthesis of (+)-leucomidine A.
基金：
National Natural Science Foundation of China [21672123]
第一作者机构：[1]Tsinghua Univ, Minist Educ, Key Lab Bioorgan Phosphorus Chem & Chem Biol, Sch Pharmaceut Sci, Beijing 100084, Peoples R China
通讯作者：
推荐引用方式(GB/T 7714)：
Yao Xiaotong,Shan Xiaosong,Zu Liansuo.Divergent Coupling of 2-Carbonyl-anilines and Diazo-cyclopentanones: Asymmetric Total Synthesis of (+)-Leucomidine A[J].ORGANIC LETTERS.2018,20(20):6498-6501.doi:10.1021/acs.orglett.8b02823.
APA：
Yao, Xiaotong,Shan, Xiaosong&Zu, Liansuo.(2018).Divergent Coupling of 2-Carbonyl-anilines and Diazo-cyclopentanones: Asymmetric Total Synthesis of (+)-Leucomidine A.ORGANIC LETTERS,20,(20)
MLA：
Yao, Xiaotong,et al."Divergent Coupling of 2-Carbonyl-anilines and Diazo-cyclopentanones: Asymmetric Total Synthesis of (+)-Leucomidine A".ORGANIC LETTERS 20..20(2018):6498-6501
化学