Values of MRI Imaging Presentations in the Hepatobiliary Phase, DWI and T2WI Sequences in Predicting Pathological Grades of Intrahepatic Mass-Forming Cholangiocarcinoma
ObjectiveTo retrospectively investigate the value of various MRI image menifestations in the hepatobiliary phase (HBP), DWI and T2WI sequences in predicting the pathological grades of intrahepatic mass-forming cholangiocarcinoma (IMCC). Materials and MethodsForty-three patients of IMCCs confirmed by pathology were enrolled including 25 cases in well- or moderately-differentiated group and 18 cases in poorly-differentiated group. All patients underwent DWI, T2WI and HBP scan. The Chi square test was used to compare the differences in the general information. Logistic regression analysis was used to analyze the risk factors in predicting the pathological grade of IMCCs. ResultsThe maximal diameter of the IMCC lesion was < 3 cm in 11 patients, between 3 cm and 6 cm in 15, and > 6 cm in 17. Sixteen cases had intrahepatic metastasis, including 5 in the well- or moderately-differentiated group and 11 in the poorly-differentiated group. Seventeen (39.5%) patients presented with target signs in the DWI sequence, including 9 in the well- or moderately-differentiated group and 8 in the poorly-differentiated group. Twenty (46.5%) patients presented with target signs in the T2WI sequence, including 8 in the well- or moderately-differentiated group and 12 in the poorly-differentiated group. Nineteen cases (54.3%) had a complete hypointense signal ring, including 13 in the well- or moderately-differentiated group and 6 in the poorly-differentiated group. Sixteen (45.7%) cases had an incomplete hypointense signal ring, including 5 in the well- or moderately-differentiated group and 11 in the poorly-differentiated group. The lesion size, intrahepatic metastasis, T2WI signal, and integrity of a hypointense signal ring in HBP were statistically significantly different between two gourps. T2WI signal, presence or non-presence of intrahepatic metastasis, and integrity of hypointense signal ring were the independent influencing factors for pathological grade of IMCC. ConclusionTarget sign in T2WI sequence, presence of intrahepatic metastasis and an incomplete hypointense-signal ring in HBP are more likely to be present in poorly-differentiated IMCCs.
基金：
Outstanding Young Scientific Research and Innovation Team of Hebei University [605020521007]; Natural Science Foundation of Hebei [H2021201017]; Colorectal Liver Metastasis and Microsatellite Instability, Medical Discipline Cultivation Project [2020B05]; Colorectal Liver Metastasis and Microsatellite Instability, The Financial Department of Hebei Province; Health commission of Hebei Province [361007]; Colorectal Liver Metastasis and Microsatellite Instability, Key Science and Technology Research Program of Hebei Province [20210789]; Gd-BOPTA in hepatobiliary stage in the identification of Intrahepatic cholangiocarcinoma and atypical liver abscess, Baoding Science and Technology Bureau project [2041ZF176]
第一作者机构：[1]Hebei Univ, Sch Clin Med, Affiliated Hosp, Baoding, Peoples R China
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推荐引用方式(GB/T 7714)：
Xing Li-Hong,Zhuo Li-Yong,Wang Jia-Ning,et al.Values of MRI Imaging Presentations in the Hepatobiliary Phase, DWI and T2WI Sequences in Predicting Pathological Grades of Intrahepatic Mass-Forming Cholangiocarcinoma[J].FRONTIERS IN ONCOLOGY.2022,12:doi:10.3389/fonc.2022.867702.
APA：
Xing, Li-Hong,Zhuo, Li-Yong,Wang, Jia-Ning,Zhang, Yan,Zhu, Feng-Ying...&Gao, Bu-Lang.(2022).Values of MRI Imaging Presentations in the Hepatobiliary Phase, DWI and T2WI Sequences in Predicting Pathological Grades of Intrahepatic Mass-Forming Cholangiocarcinoma.FRONTIERS IN ONCOLOGY,12,
MLA：
Xing, Li-Hong,et al."Values of MRI Imaging Presentations in the Hepatobiliary Phase, DWI and T2WI Sequences in Predicting Pathological Grades of Intrahepatic Mass-Forming Cholangiocarcinoma".FRONTIERS IN ONCOLOGY 12.(2022)
