Objective. The purpose of this study was to systematically evaluate the efficacy and safety of acupuncture combined with the WHO three-step analgesic drug ladder for cancer pain. Methods. The Cochrane Library, PubMed, and CNKI Database of Systematic Reviews were searched. Using the Cochrane Register for Randomized Controlled Trials, the quality of the included literature was evaluated, and the meta-analysis was carried out with RevMan 5.3 software. Results. Compared with three-step analgesia alone, acupuncture combined with three-step analgesia for cancer pain increased pain relief response rates (RR = 1.12, 95% CI: 1.08 similar to 1.17, P<0.00001), reduced NRS score (SMD = -1.10, 95% CI: -1.86 similar to-0.35, P=0.004), reduced the rate of side effects (RR = 0.45, 95% CI: 0.38 similar to 0.53, P<0.00001), including nausea (P<0.00001), vomiting (P=0.008), constipation (P<0.00001), and dizziness (P=0.010), reduced the burst pain rate (SMD = -1.38; 95% CI: -2.44 similar to-0.32, P=0.01), shortened analgesia effect onset time (P=0.004), and extended the duration of response (P<0.0001). Conclusion. For the treatment of cancer pain, acupuncture combined with three-step analgesic drugs is better than using only three-step analgesic drugs.