机构：[1]Tianjin Medical University Graduate School, Tianjin, 300070, PR China[2]Department of Gynecology and Obstetrics,Affiliated Hospital of Hebei University,Baoding,Hebei,071000,PR China河北大学附属医院重点学科妇科[3]Department of Gynecologic Oncology, Tianjin Central Hospital of Obstetrics and Gynecology, Tianjin, 300199, PR China
microRNA-152 (miR-152) is a tumor suppressor that is down-regulated in many cancers including endometrial cancer (EC). However, the underlying mechanism of action of miR-152 in EC is unclear. The aim of the present study was to evaluate the role of miR-152 on proliferation of human endometrial cancer cells. Herein, we found that miR-152 overexpression and CDC25B knockdown inhibited proliferative ability and induced G2/M phase arrest in KLE and HEC-1B cells. CDC25B was a target of miR-152. In addition, CDC25B overexpression rescued miR-152-induced proliferation inhibition and G2/M phase arrest in human endometrial cancer cells. The results indicated that miR-152 was a tumor suppressor in EC that inhibited proliferation of human endometrial cancer cells via inducing G2/M phase arrest by suppressing CDC25B expression.
语种：
外文
被引次数：
WOS：
PubmedID：
中科院(CAS)分区：
出版当年[2019]版：
大类|3 区医学
小类|3 区医学：研究与实验3 区药学
最新[2025]版：
大类|2 区医学
小类|2 区医学：研究与实验2 区药学
JCR分区：
出版当年[2018]版：
Q1PHARMACOLOGY & PHARMACYQ2MEDICINE, RESEARCH & EXPERIMENTAL
最新[2023]版：
Q1MEDICINE, RESEARCH & EXPERIMENTALQ1PHARMACOLOGY & PHARMACY
第一作者机构：[1]Tianjin Medical University Graduate School, Tianjin, 300070, PR China
通讯作者：
通讯机构：[3]Department of Gynecologic Oncology, Tianjin Central Hospital of Obstetrics and Gynecology, Tianjin, 300199, PR China [*1]Department of Gynecologic Oncology, Tianjin Central Hospital of Obstetrics and Gynecology, No. 156 Nankai Three Road, Tianjin 300199, PR China
推荐引用方式(GB/T 7714)：
Xie Dan,Liang Yijuan,Su Yuanyuan,et al.miR-152 inhibits proliferation of human endometrial cancer cells via inducing G2/M phase arrest by suppressing CDC25B expression[J].BIOMEDICINE & PHARMACOTHERAPY.2018,99:299-305.doi:10.1016/j.biopha.2018.01.046.
APA：
Xie, Dan,Liang, Yijuan,Su, Yuanyuan,An, Yan&Qu Pengpeng.(2018).miR-152 inhibits proliferation of human endometrial cancer cells via inducing G2/M phase arrest by suppressing CDC25B expression.BIOMEDICINE & PHARMACOTHERAPY,99,
MLA：
Xie, Dan,et al."miR-152 inhibits proliferation of human endometrial cancer cells via inducing G2/M phase arrest by suppressing CDC25B expression".BIOMEDICINE & PHARMACOTHERAPY 99.(2018):299-305
