miR-193b-3p was found to be downregulated and contributed to ovarian cancer (OC) progression. In the present study, we aimed to study the detailed role of miR-193b-3p in the development of OC and the underlying molecular mechanism. The results showed that miR-193b-3p was downregulated while PAK3 was upregulated in OC cells. Ectopic expression of miR-193b-3p and PAK3 knockdown repressed cell proliferation, promoted paclitaxel-induced cytotoxicity, and reinforced paclitaxel-mediated caspase-3 activity increase in OC cells. Notably, miR-193b-3p was identified to directly target PAK3 and suppressed PAK3 expression. Moreover, enforced expression of PAK3 partially overturned the effects of miR-193b-3p on OC cell proliferation and paclitaxel sensitivity. In conclusion, miR-193b-3p possessed anti-tumor activity in OC through inhibiting cell proliferation and enhancing paclitaxel sensitivity by targeting PAK3. Therefore, our study suggested that the miR-193b-3p/PAK3 axis might be a potential novel therapeutic target for OC.
语种：
外文
被引次数：
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PubmedID：
中科院(CAS)分区：
出版当年[2018]版：
大类|3 区医学
小类|3 区医学：研究与实验3 区药学
最新[2025]版：
大类|2 区医学
小类|2 区医学：研究与实验2 区药学
JCR分区：
出版当年[2017]版：
Q2PHARMACOLOGY & PHARMACYQ2MEDICINE, RESEARCH & EXPERIMENTAL
最新[2023]版：
Q1MEDICINE, RESEARCH & EXPERIMENTALQ1PHARMACOLOGY & PHARMACY
第一作者机构：[1]Department of Obstetrics and Gynecology, Affiliated Hospital of Hebei University, Baoding, Hebei 071000, PR China
共同第一作者：
通讯作者：
通讯机构：[1]Department of Obstetrics and Gynecology, Affiliated Hospital of Hebei University, Baoding, Hebei 071000, PR China[*1]Department of Obstetrics and Gynecology, Affiliated Hospital of Hebei University, No. 212 Yuhua East Road, Baoding, Hebei 071000, PR China
推荐引用方式(GB/T 7714)：
Zhang Jinzhi,Qin Jinjin,Su Yuanyuan.miR-193b-3p possesses anti-tumor activity in ovarian carcinoma cells by targeting p21-activated kinase 3[J].BIOMEDICINE & PHARMACOTHERAPY.2017,96:1275-1282.doi:10.1016/j.biopha.2017.11.086.
APA：
Zhang, Jinzhi,Qin, Jinjin&Su, Yuanyuan.(2017).miR-193b-3p possesses anti-tumor activity in ovarian carcinoma cells by targeting p21-activated kinase 3.BIOMEDICINE & PHARMACOTHERAPY,96,
MLA：
Zhang, Jinzhi,et al."miR-193b-3p possesses anti-tumor activity in ovarian carcinoma cells by targeting p21-activated kinase 3".BIOMEDICINE & PHARMACOTHERAPY 96.(2017):1275-1282
