机构：[1]Hebei Med Univ, Sch Pharmaceut Sci, Shijiazhuang 050017, Hebei, Peoples R China[2]Hebei Ind Microbial Metab Engn & Technol Res Ctr, Natl Microbial Med Engn & Res Ctr, Key Lab New Drug Screening Technol Shijiazhuang C, North China Pharmaceut Grp Corp,New Drug Res & De, Shijiazhuang 050015, Hebei, Peoples R China[3]Hebei Med Univ, Collaborat Innovat Ctr Forens Med Mol Identi cati, Hebei Key Lab Forens Med, Shijiazhuang 050017, Hebei, Peoples R China[4]Queens Univ, Dept Chem, Kingston, ON K7L 3N6, Canada[5]Syngenta Jealotts Hill Int Res Ctr, Bracknell RG42 6EY, Berks, England[6]Hebei Univ, Sch Basic Med Sci, Affiliated Hosp, Baoding 071000, Peoples R China河北大学附属医院
Twelve new compounds, aspergorakhins A-L (1-12) coupled with one known xanthone leptosphaerin D (13), were isolated from the extract of soil-derived fungus Aspergillus gorakhpurensis F07ZB1707. Their structures were elucidated by spectroscopic data analysis including UV, IR, NMR, and HRESIMS. The absolute configurations of 5 and 8-11 were identified using ECD and OR calculations. All compounds were tested by enzyme inhibitory activity assay in vitro. Aspergorakhin A (1) showed selective activities against PTP1B and SHP1 over TCPTP with IC50 values 0.57, 1.19, and 22.97 mu M, respectively. Compounds 1 and 2 exhibited modest cytotoxicity against tumor cell lines A549, HeLa, Bel-7402, and SMMC-7721 with IC50 values in the range of 6.75-83.4 mu M.
基金：
Natural Science Foundation of Hebei Province [H2020206599]; Syngenta Ltd. (Hebei Medical University-Syngenta) [12112020]
第一作者机构：[1]Hebei Med Univ, Sch Pharmaceut Sci, Shijiazhuang 050017, Hebei, Peoples R China
通讯作者：
通讯机构：[1]Hebei Med Univ, Sch Pharmaceut Sci, Shijiazhuang 050017, Hebei, Peoples R China[3]Hebei Med Univ, Collaborat Innovat Ctr Forens Med Mol Identi cati, Hebei Key Lab Forens Med, Shijiazhuang 050017, Hebei, Peoples R China
推荐引用方式(GB/T 7714)：
Ji Yannan,Zhou Qiqi,Liu Guosheng,et al.New protein tyrosine phosphatase inhibitors from fungus Aspergillus gorakhpurensis F07ZB1707[J].RSC ADVANCES.2021,11(17):10144-10153.doi:10.1039/d1ra00788b.
APA：
Ji, Yannan,Zhou, Qiqi,Liu, Guosheng,Zhu, Tianhui,Wang, Yufang...&Ni, Zhiyu.(2021).New protein tyrosine phosphatase inhibitors from fungus Aspergillus gorakhpurensis F07ZB1707.RSC ADVANCES,11,(17)
MLA：
Ji, Yannan,et al."New protein tyrosine phosphatase inhibitors from fungus Aspergillus gorakhpurensis F07ZB1707".RSC ADVANCES 11..17(2021):10144-10153
