Background: Three operative techniques: anterior cervical discectomy and fusion (ACDF), anterior cervical corpectomy and fusion (ACCF) and Hybrid Surgery (HS), corpectomy combined with discectomy, are used to treat multilevel cervical spondylotic myelopathy (CSM). However, which one is the best treatment for multilevel CSM remains considerable controversy. Objective: A meta-analysis was performed to compare the clinical, radiographic and surgical outcomes among three surgical methods in the treatment for multilevel CSM. Methods: An extensive search of literature was performed in Pubmed/MEDLINE, Embase, the Cochrane library, CNKI and WANFANG databases on three operative techniques treating multilevel CSM from Jan. 2010 to Jan. 2017. The following variables were extracted: length of hospital stay, blood loss, operation time, Japanese Orthopedic Association scores (JOA), neck disability index score (NDI), fusion rate, Cobb angles of C2-C7, dysphagia, hoarseness, C5 palsy, infection, cerebral fluid leakage, epidural hematoma, graft subsidence, graft dislodgment and total complications. Data analysis was conducted with RevMan 5.3 and STATA 12.0. Results: A total of 12 studies with 1468 patients were included in our study. The results showed that there were significant differences among three methods in blood loss and total complications (all p<0.05). ACDF were better in the angle of C2-C7 at the final follow-up (p<0.00001), C5 plasy (p=0.02), fusion rate (p=0.04) and graft subsidence (p=0.004) than ACCF. In term of angle of C2-C7 at final follow-up (p<0.00001), operation time (p=0.003), fusion rate (p=0.02) and hospital stay (p<0.00001), HS was better than ACCF. Conclusions: Based on our meta-analysis, except for blood loss and total complications, ACDF and hybrid surgery are effective choices for the treatment of multilevel CSM and ACCF is the last option.