Iron deficiency is very common in untreated dialysis patients, and hemochromatosis should be rare in theory. However, large doses of intravenous iron injection may cause hemochromatosis. We report two cases of hemochromatosis that resulted from a large dose of intravenous iron injection in hemodialysis patients. Clinical manifestations included liver enlargement, liver fibrosis or even cirrhosis, splenomegaly and other solid organ dysfunctions. Case one manifested as liver cirrhosis and case two manifested as confusion in consciousness. These two cases both manifested as thrombocytopenia, and increased density of the liver and spleen. The two patients' condition was serious, eventually both patients died a few days later.