As reported in many research, LncRNA CTBP1 divergent transcript (CTBP1-AS2) remarkably affects the progression of several tumors. However, the precise role and function of CTBP1-AS2 in hepatocellular carcinoma (HCC) remained unknown. We found that CTBP1-AS2 expressions were increased in HCC samples and cells. After treatment with microwave ablation (MWA), CTBP1-AS2 was distinctly up regulated in residual HCC tissues compared with HCC samples. CTBP1-AS2 was upregulated under the induction of the nuclear transcription factor SP1. As revealed by the clinical assays, high CTBP1-AS2 expression usually related to lymph node metastasis, clinical stage and weaker prognosis specific to HCC patients. Functionally, CTBP1-AS2 knockdown suppressed HCC cells in terms of the proliferation, migration, invasion, chemotherapy resistance as well as EMT progress, but promoted apoptosis. Mechanistically, CTBP1-AS2 was a sponge of miR-195-5p for elevating CEP55 expression, a target of miR-1955p, and thereby exhibited its oncogenic roles in HCC progression. Overall, an emerging regulatory mechanism of SP1/CTBP1-AS2/miR-195-5p/CEP55 axis was reported in the paper, which possibly served as a new therapeutic HCC treatment target. (c) 2020 Elsevier Inc. All rights reserved.
基金：
Medical Science Foundation of Hebei University [2020B08]
第一作者机构：[1]Chinese Peoples Liberat Army Gen Hosp, Med Sch Chinese PLA, Dept Intervent Ultrasound, 28 Fuzing Rd, Beijing 100853, Peoples R China[2]Hebei Univ, Affiliated Hosp, Dept Ultrasound, Baoding 071000, Hebei, Peoples R China
共同第一作者：
通讯作者：
通讯机构：[1]Chinese Peoples Liberat Army Gen Hosp, Med Sch Chinese PLA, Dept Intervent Ultrasound, 28 Fuzing Rd, Beijing 100853, Peoples R China[*1]Department of Interventional Ultrasound, Chinese PLAGeneral Hospital, Medical School of Chinese PLA, No. 28, Fuxing Road, Haidian,100853, Beijing, China
推荐引用方式(GB/T 7714)：
Liu Li-xia,Liu Bin,Yu Jie,et al.SP1-induced upregulation of lncRNA CTBP1-AS2 accelerates the hepatocellular carcinoma tumorigenesis through targeting CEP55 via sponging miR-195-5p[J].BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS.2020,533(4):779-785.doi:10.1016/j.bbrc.2020.09.080.
APA：
Liu, Li-xia,Liu, Bin,Yu, Jie,Zhang, Dong-yun,Shi, Jian-hong&Liang, Ping.(2020).SP1-induced upregulation of lncRNA CTBP1-AS2 accelerates the hepatocellular carcinoma tumorigenesis through targeting CEP55 via sponging miR-195-5p.BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,533,(4)
MLA：
Liu, Li-xia,et al."SP1-induced upregulation of lncRNA CTBP1-AS2 accelerates the hepatocellular carcinoma tumorigenesis through targeting CEP55 via sponging miR-195-5p".BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 533..4(2020):779-785
