机构：[1]Department of Pharmacology, Institute of Chinese Integrative Medicine, Hebei Medical University, Shijiazhuang 050017, China[2]Department of Anesthesiology, Affiliated Hospital of Hebei University, Baoding 071000, China河北大学附属医院
Abstract P2X1 receptors and adrenoceptors are mainly responsible for vasoconstriction in a
variety of blood vessels. However, previous studies have shown that a,b-methylene adenosine
50
-triphosphate (a,b-MeATP), a stable analogue of ATP, can induce both pressor and depressor
responses in laboratory animals. In this study, the effects of increasing intravenous doses of a,bMeATP and noradrenaline (NA) (0–30 nmol/kg) administered at 20 min intervals on systolic
(SBP), diastolic (DBP) and mean (MBP) blood pressure in groups of anesthetized mice (n¼6) were
compared. Both a,b-MeATP and NA caused transient, dose-dependent increases in SBP, DBP and
MBP but the effect of a,b-MeATP was more rapid and significantly larger at doses of 10 and
30 nmol/kg (Po0.01). At the dose of 30 nmol/kg, a,b-MeATP increased SBP, DBP and MBP by
65.877.0, 65.775.0 and 65.775.5 mmHg, respectively, compared to increases of 36.874.6,
33.374.9 and 34.574.7 mmHg, respectively, produced by NA. These results indicate P2X1
receptors play an important role in BP regulation although purinergic vasoconstriction alone
may not explain the more potent pressor response to a,b-MeATP in the anesthetized mouse.
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大类|1 区医学
小类|1 区药学
第一作者：
第一作者机构：[1]Department of Pharmacology, Institute of Chinese Integrative Medicine, Hebei Medical University, Shijiazhuang 050017, China[2]Department of Anesthesiology, Affiliated Hospital of Hebei University, Baoding 071000, China
通讯作者：
推荐引用方式(GB/T 7714)：
Lu Li,Yi Wu,Mo Deng,et al.P2X1 receptor-mediated pressor responses in the anesthetized mouse[J].Acta Pharmaceutica Sinica B.2012,2(5):459-463.doi:10.1016/j.apsb.2012.04.005.
APA：
Lu Li,Yi Wu,Mo Deng,Guangyi Wu&Leiming Ren.(2012).P2X1 receptor-mediated pressor responses in the anesthetized mouse.Acta Pharmaceutica Sinica B,2,(5)
MLA：
Lu Li,et al."P2X1 receptor-mediated pressor responses in the anesthetized mouse".Acta Pharmaceutica Sinica B 2..5(2012):459-463
医学